Most Mac users would use at least a few keyboard shortcuts (if not, check out Apple’s Mac Keyboard Shortcuts list), but here are a few additional key combinations that I find useful. These are less well-known and many are not in Apple’s list.

KeystrokeAction
Option-Shift-Command-VPaste as text / paste and match style
Option-[“ (opening curly double quote)
Option-Shift-[” (closing curly double quote)
Option-]‘ (opening curly quote)
Option-Shift-]’ (closing curly quote)
Fn-DeleteForward delete
Fn-UpPage up
Fn-DownPage down
Fn-LeftHome
Fn-RightEnd
Option-3£
Option-4¢
Option-Y¥
Command-SpaceSpotlight Search
Option-Command-SpaceSearch “This Mac”
Shift-Command-5Screenshot (Mojave)
Shift-Command-.Finder Show Hidden Files

Updated 10 Apr 2020: Added Show hidden files in Finder.